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KMID : 0613820200300030278
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Journal of Life Science
2020 Volume.30 No. 3 p.278 ~ p.284
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Antibacterial and Anti-inflammatory Effects of Essential Oil from the Magnolia kobus Flower
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Lee Jae-Yeul
Jhee Kwang-Hwan
Yang Seun-Ah
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Abstract
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Magnolia kobus is known to exert various biological effects, such as antioxidant and hypnotic activity. In this study, we investigated the antimicrobial and anti-inflammatory activity of M. kobus essential oil extracted using steam distillation. Its antimicrobial activity was tested against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa by the paper disk diffusion and minimum inhibitory concentration (MIC) methods. Its anti-inflammatory activity was evaluated by measuring its inhibition ratio on the production of nitric oxide (NO) and PGE2 in lipopolysaccharide (LPS)-induced RAW264.7 cells. Its composition was analyzed by gas chromatography?mass spectrometry (GC-MS). The results showed that M. kobus essential oil exhibited excellent antibacterial activity against S. aureus, with a clear zone of 18 mm and an MIC value of 0.25 mg/ml. Its clear zones against P. aeruginosa and E. coli were 14 mm and 17 mm, respectively, while its MIC values were 1 mg/ml and 0.5 mg/ml, respectively. The essential oil exhibited no cytotoxicity to the RAW264.7 cells at a concentration of 500 μg/ml while showing NO (37.7%) and PGE2 inhibition (24.0%). Its three main fragrance ingredients identified were 3-carene (77.07%), β-elemene (6.92%), and caryphyllene (2.86%). The results suggest that M. kobus essential oil has potential as a cosmetic functional material with antimicrobial and anti-inflammatory effects.
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KEYWORD
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Anti-bacterial activity, anti-inflammation activity, essential oil, Magnolia kobus
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